Dr. Wang recently joined CUNY Advanced Science Research Center as Imaging Facility manager and research assistant professor. Before joining CUNY ASRC Dr. Wang was a post_doc and biological associate at Brookhaven National Lab. Over the past several years at BNL, His research has been focused on molecular imaging by TEM (e.g. negatively stained TEM and cryo-EM) and on structural analysis of large biological molecular machines and the DNA-based functional nanomaterials. He has successfully determined the structures of several important protein machines, including a photo-sensory protein originated from bacteria. More recently Dr. Wang worked on the self-assembly mechanism of nanoparticle clusters organized by rigid DNA frames, and quite satisfactorily, he showed by single particle cryo-EM that the structures indeed assembled as designed. Dr. Wang’s doctoral dissertation and early career training were in the field of DNA nanotechnology at New York University focusing on two themes: the fabrication and characterization of DNA-based nanostructures ranging from 1D to 3D, and the creation of a novel information-bearing nanomaterial, which could in principle replicate much like DNA replication in the living systems.
Dr. Wang is interested in developing an interdisciplinary research program, involving structural biology, chemistry, biotechnology, and nanomaterials, which includes the following directions: DNA-templated functional nanomaterials fabrication (multi-dimension) and characterization, bio-inspired artificial molecular assemblies at nanometer scale, DNA nanostructure based stimuli-responsive drug delivery systems, and structural analysis of native protein complexes by cryo-electron microscopy and single particle reconstruction.
- L. Bai, T. Wang, G. Zhao, A. Kovach, H. Li, The atomic structure of a eukaryotic oligosaccharyltransferase complex, Nature, 2018, 555, 328-333
- E. Burgie, A. Bussell, S. Lye, T. Wang, W. Hu, K. McLoughlin, E. Weber, H. Li, R. Vierstra, Photosensing and Thermosensing by Phytochrome B Require Both Proximal and Distal Allosteric Features within the Dimeric Photoreceptor, Sci. Rep., 2017, 7(1), 13648
- C. Zhang, R. Shafi, A. Lampel, D. macPherson, C. Pappas, V. Narang, T. Wang, C. Madarelli, R. Ulijn, Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self-Assembling Peptide, Angew. Chem. Itd. Ed., 2017, 56(46), 14511-14515
- F. Hong, S. Jiang, T. Wang, Y. Liu, H. Yan, Framework DNA Origami Nanostructures with Layered-Crossover Motifs, Angew. Chem. Int. Ed., 2016, 55(41, 12832-12835
- Y. Tian, T. Wang, W. Liu, H. Xin, H. Li, Y. Ke, W. Shih adn O. Gang, Mesoscale 3D Nanoparticle Clusters with Prescribed Architectures, Nature Nanotechnology, 2015, 10, 637-644
- E.S. Burgie, T. Wang, A.N. Bussell, J.M. Walker, H. Li and R.D. Vierstra, Crystallographic and Electron Microscopic Analyses of a Bacterial Phytochrome Reveal Local and Global Rearrangements During Photoconversion, J. Biol. Chem., 2014, 289, 24573-24587
- T. Wang, D. Schiffels, S. Martinez, D.K. Fygenson and N.C. Seeman, Design and Characterization of 1D Nanotubes and 2D Periodic Arrays Self-Assembled from DNA Multi-Helix Bundles, J. Am. Chem. Soc., 2012, 134(3), 1606-1616
- T. Wang, R. Sha, R. Dreyfus, M.E. Leunissen, C. Maass, D.J. Pine, P.M. Chaikin and N.C. Seeman, Self-replication of information-bearing nanoscale patterns, Nature, 2011, 478, 225-228
- T. Wang, R. Sha, J.J. Birktoft, J. Zheng, C. Mao and N.C. Seeman, A DNA Crystal Designed to Contain Two Asymmetric Units, J. Am. Chem. Soc, 2010, 132(44), 15471-15473
- 2015 - Current : Imaging Facility Manager, CUNY Advanced Science Research Center
- 2009 - 2015 : Postdoctoral Research Associate and Biological Associate, Brookhaven National Laboratory
- 2007 - 2009 : Postdoctoral Research Associate, New York University
- 2001 - 2007 : PhD candidate, New York University