Research Interests

I am establishing a new laboratory focused on the development of novel bio-inspired nanoplatforms for the diagnosis and treatment of local inflammation in diseases such as sepsis, rheumatoid arthritis, atherosclerosis, and cancer. My work follows an interdisciplinary approach to generate synergy among chemistry, nanotechnology, bioengineering, surface analysis and cell biology in order to radically improve the potency of small molecules, biopharmaceuticals and contrast agents. Additionally, I am interested in developing quantitative tools and methods to measure nanoparticles’ stability, biodistribution, pharmacokinetics, and therapeutic efficacy.

 

Publications

  • B.L. Sanchez-Gaytan, F. Fay, S. Hak, A. Alaarg, Z.A. Fayad, C. Pérez-Medina, W.J.M. Mulder and Y. Zhao, Real-Time Monitoring of Nanoparticle Formation by FRET Imaging, Angew Chem, 2017, in press,
  • P. Ramos-Cabrer, F. Fay, B.L. Sanchez-Gaytan, J. Tang, J. Castillo, Z.A. Fayad and W.J.M. Mulder, Conformational Changes in High-Density Lipoprotein Nanoparticles Induced by High Payloads of Paramagnetic Lipids, ACS Omega, 2016, 1, 470-475
  • Y. Zhao, F. Fay F, S. Hak, J.M. Perez-Aguilar, B.L. Sanchez-Gaytan, B. Goode, C. de Lange Davies, A. Bjørkøy, H. Weinstein, Z.A. Fayad, C. Pérez-Medina and W.J.M Mulder, Augmenting drug-carrier compatibility improves tumor nanotherapy efficacy, Nat. Commun, 2016, 7, 11221
  • B.L. Sanchez-Gaytan*, F. Fay*, M.E. Lobatto*, J. Tang, M. Ouimet, Y. Kim, S.E. van der Staay, S.M. van Rijs, B. Priem, L. Zhang, E.A Fisher, K.J. Moore, R. Langer, Z.A. Fayad, W.J.M. Mulder, HDL-mimetic PLGA nanoparticle for the targeting of atherosclerosis plaque macrophages, Bioconjug Chem, 2015, 26, 443-451
  • Y. Kim*, F. Fay*, D.P Cormode, B.L. Sanchez-Gaytan,J. Tang, E.J. Hennessy, M. Ma, K.J. Moore, O.C. Farokhzad, E.A. Fisher, W.J.M Mulder, R. Langer, Z.A. Fayad, Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics, ACS Nano, 2013, 7, 9975-9983

 

Job History

  • 2016 - Current : Assistant Professor, York College
  • 2012 - 2016 : Postdoctoral Fellow, TMII Icahn School of Medicine at Mount Sinai, NY
  • 2010 - 2012 : Postdoctoral Fellow, School of Pharmacy, Queen’s University Belfast, UK
  • 2006 - 2010 : Ph.D. Pharmacy, Queen’s University Belfast, UK
  • 2003 - 2006 : M.Sc. Biotechnology, ENSTBB, Bordeaux University, France
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